Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese

doi:10.4239/wjd.v13.i8.643

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Aug 15, 2022; 13(8): 643-653
Published online Aug 15, 2022. doi: 10.4239/wjd.v13.i8.643

Table 7 Association of rs1137101 with hypertension and type 2 diabetes mellitus (hypertension and hypertension + type 2 diabetes mellitus)

Model	Genotype	Han, n = 892				Mongolian, n = 852
Model	Genotype	Control, n (%)	HTN with T2DM, n (%)	OR (95%CI)	P value	Control, n (%)	HTN with T2DM, n (%)	OR (95%CI)	P value
Co-dominant	G/G	312 (76.8)	394 (81.1)	1	0.034	436 (66.6)	151 (76.7)	1	0.0067
	A/G	91 (22.4)	84 (17.3)	0.65 (0.46-0.92)		202 (30.8)	42 (21.3)	0.54 (0.36-0.81)
	A/A	3 (0.7)	8 (1.6)	1.61 (0.41-6.28)		17 (2.6)	4 (2.0)	0.55 (0.17-1.79)
Dominant	G/G	312 (76.8)	394 (81.1)	1	0.026	436 (66.6)	151 (76.7)	1	0.0016
Dominant	A/G-A/A	94 (23.1)	92 (18.9)	0.68 (0.49-0.96)	0.026	219 (33.4)	46 (23.4)	0.54 (0.36-0.80)	0.0016
Recessive	G/G-A/G	403 (99.3)	478 (98.3)	1	0.39	638 (97.4)	193 (98.0)	1	0.46
Recessive	A/A	3 (0.7)	8 (1.6)	1.77 (0.46-6.87)	0.39	17 (2.6)	4 (2.0)	0.65 (0.20-2.11)	0.46
Over-dominant	G/G-A/A	315 (77.6)	402 (82.7)	1	0.012	453 (69.2)	155 (78.7)	1	0.0028
Over-dominant	A/G	91 (22.4)	84 (17.3)	0.65 (0.46-0.91)	0.012	202 (30.8)	42 (21.3)	0.55 (0.37-0.82)	0.0028
Log-additive	-	-	-	0.75 (0.55-1.02)	0.067	-	-	0.59 (0.41-0.84)	0.0024

Adjusted for sex and age. P value of < 0.05 was considered significant. OR: Odd ratio; HTN: Hypertension; T2DM: Type 2 diabetes mellitus; CI: Confidence interval.

Citation: Zhao KY, Yuan ML, Wu YN, Cui HW, Han WY, Wang J, Su XL. Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese. World J Diabetes 2022; 13(8): 643-653
URL: https://www.wjgnet.com/1948-9358/full/v13/i8/643.htm
DOI: https://dx.doi.org/10.4239/wjd.v13.i8.643