Case Control Study
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World J Diabetes. Aug 15, 2022; 13(8): 643-653
Published online Aug 15, 2022. doi: 10.4239/wjd.v13.i8.643
Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese
Ke-Yu Zhao, Meng-Lu Yuan, Yun-Na Wu, Hong-Wei Cui, Wen-Yan Han, Jing Wang, Xiu-Lan Su
Ke-Yu Zhao, Xiu-Lan Su, Clinical Medical Research Center of The Affiliated Hospital, Inner Mongolia Key Laboratory of Medical Cellular Biology, Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China
Meng-Lu Yuan, School of Public Health, Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China
Yun-Na Wu, Medical Clinical Laboratory, Huhhot First Hospital, Huhhot 010050, Inner Mongolia Autonomous Region, China
Hong-Wei Cui, Department of Scientific Research, Inner Mongolia Autonomous Region Cancer Hospital/The Affiliated People’s Hospital of Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China
Wen-Yan Han, Clinical Medical Laboratory Center, The Second Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China
Jing Wang, Graduate School, Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China
Author contributions: Zhao KY, Yuan ML, Wu YN, Cui HW, Han WY, Wang J and Su XL designed the research study; Zhao KY, Wang J, Yuan ML and Su XL performed the research; Su XL and Zhao KY contributed new reagents and analytic tools; Zhao KY, Yuan ML and Su XL analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81260058.
Institutional review board statement: The study was reviewed and approved by the Affiliated Hospital of Inner Mongolia Medical University Institutional Review Board, No. 2015003.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu-Lan Su, MMed, Professor, Clinical Medical Research Center of The Affiliated Hospital, Inner Mongolia Key Laboratory of Medical Cellular Biology, Inner Mongolia Medical University, No. 1 North Tongdao Road, Hohhot, 010050, Inner Mongolia Autonomous Region, China. xlsu@sina.com
Received: February 17, 2022
Peer-review started: February 17, 2022
First decision: May 30, 2022
Revised: June 14, 2022
Accepted: July 26, 2022
Article in press: July 26, 2022
Published online: August 15, 2022
Core Tip

Core Tip: Hypertension and type 2 diabetes mellitus are often coincident, and each condition is a risk factor for the other. It is unknown why there are differences in risk between Han and Mongolian ethnic groups. The LEPR gene and its polymorphism, rs1137101 (Gln223Arg), are considered risk factors for the occurrence of hypertension and type 2 diabetes mellitus. The current study investigated the relationship between rs1137101 and the occurrence of hypertension with type 2 diabetes mellitus in Mongolian and Han populations in Inner Mongolia. Differences between the two populations were analyzed. The aim was to inform further research on advanced metabolic disease.