Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease

Table 1 Major components of the glomerular basement membrane and the mesangial matrix in normal human glomeruli

	Glomerular basement membrane	Mesangial matrix
Heparan sulfate proteoglycan	Abundant	Abundant
Laminin	Major component	Minor component
Fibronectin	Minor component	Major component
Type I collagen	Absent in most studies	Absent in most studies
Type III collagen	Absent in most studies	Absent in most studies
Type IV collagen	Major component	Present (inconsistent amounts)
Type V collagen	Present	Present
Type VI collagen	Present	Present
Type XVII collagen	Present	Unknown
Type XVIII collagen	Present	Present
Tubulointerstitial nephritis antigen-like-1	Low abundance	High abundance
Nidogen / Entactin	Present	Low abundance
Fibulin-1	Present	Present
Fibrillin-1	Present	Present
Nephronectin	Present	Present
Vitronectin	Absent	Present
Microfibril-associated proteins	Absent	Present