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World J Diabetes. Aug 15, 2014; 5(4): 557-561
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.557
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.557
Study of factors influencing susceptibility and age at onset of type 1 diabetes: A review of data from Continental Italy and Sardinia
Fulvia Gloria-Bottini, Patrizia Saccucci, Luca Coppeta, Anna Neri, Andrea Magrini, Bottini Egidio, Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Gian Franco Meloni, Department of Pediatrics, University of Sassari Medical School, 07010 Sassari, Italy
Maria Luisa Manca-Bitti, Pediatric Diabetology and Endocrinology Unit, Policlinico Tor Vergata, University Hospital, 00144 Rome, Italy
Author contributions: Gloria-Bottini F, Meloni GF, Magrini A and Egidio B designed the study and contributed to write the manuscript; Saccucci P and Manca-Bitti ML performed the majority of experiments. Meloni GF, Coppeta L and Neri A provided the collection of human material and clinical data; Gloria-Bottini F and Egidio B performed statistical analyses; all authors read and approved the manuscript.
Correspondence to: Fulvia Gloria-Bottini, MD, Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy. gloria@med.uniroma2.it
Telephone: +39-06-30889514
Received: November 27, 2013
Revised: June 9, 2014
Accepted: June 20, 2014
Published online: August 15, 2014
Revised: June 9, 2014
Accepted: June 20, 2014
Published online: August 15, 2014
Core Tip
Core tip: It is known that the incidence of type 1 diabetes (T1D) is greater in Sardinian than in Italian population. Among the factors considered in this review maternal age only has shown a significant difference between the two populations. Although in both Sardinia and Continental Italy the proportion of mothers aging more than 32 years is higher in children with T1D than in consecutive newborns from the same population, the risk of having a child with T1D in younger women is much greater in Sardinia than in Continental Italy (OR = 17.191 vs 2.018).