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World J Diabetes. Aug 15, 2014; 5(4): 482-492
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.482
Effects of exercise training on mitochondrial function in patients with type 2 diabetes
Steen Larsen, Stinna Skaaby, Jørn W Helge, Flemming Dela
Steen Larsen, Stinna Skaaby, Jørn W Helge, Flemming Dela, Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
Author contributions: Larsen S generated the data and wrote the review; Larsen S, Skaaby S, Helge JW and Dela F contributed to discussion and reviewed and edited the manuscript.
Correspondence to: Steen Larsen, DMSci, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark. stelar@sund.ku.dk
Telephone: +45-35-327457 Fax: +45-35-327420
Received: December 16, 2013
Revised: May 23, 2014
Accepted: June 10, 2014
Published online: August 15, 2014
Core Tip

Core tip: It is well described that exercise interventions improves insulin sensitivity and maximal oxygen uptake in patients with type 2 diabetes as well as in control subjects. When it comes to adaptations in mitochondrial function after an exercise intervention the literature is more sparse especially in patients with type 2 diabetes. Furthermore the medication that patients with type 2 diabetes are using, are often not described well in the papers, and it is known that the different medication (statins and antihypertensive agents) have a major effect on mitochondrial function and insulin sensitivity.