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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2023; 14(12): 1824-1838
Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1824
Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1824
Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice
Qi-Yan Sun, Xu-Ye Wang, Fang-Hua Gong, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
Qi-Yan Sun, Zhejiang Medical Products Service Center, Hangzhou 310012, Zhejiang Province, China
Zu-Pin Huang, Jing Song, En-Dong Zheng, Fang-Hua Gong, Xiao-Wang Huang, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cangnan Hospital of Wenzhou Medical University, Wenzhou 325800, Zhejiang Province, China
Author contributions: Sun QY, Wang XY and Huang ZP contributed equally to this work; Gong FH and Huang XW conceived the experiments, analyzed the data; Sun QY, Wang XY, Huang ZP, Song J and Zheng ED performed experiments, coordinated the study and oversaw all experiments, revised the paper; all authors discussed the results and commented on the manuscript.
Supported by the 2022 Zhejiang Provincial Health Science and Technology Plan , No. 2022KY1216 .
Institutional review board statement: This study did not involve human experimentation.
Institutional animal care and use committee statement: The study was reviewed and approved by the Ethics Committee of the Laboratory Animal of Wenzhou Medical University Institutional Review Board (Approval No.xmsq2023-0426).
Conflict-of-interest statement: The author declare that there is no conflict of interest regarding the publication of this manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Wang Huang, MD, Chief Physician, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cangnan Hospital of Wenzhou Medical University, No. 2288 Yucang Road, Lingxi Town, Wenzhou 325800, Zhejiang Province, China. hxw7@163.com
Received: August 22, 2023
Peer-review started: August 22, 2023
First decision: September 18, 2023
Revised: September 28, 2023
Accepted: November 25, 2023
Article in press: November 25, 2023
Published online: December 15, 2023
Peer-review started: August 22, 2023
First decision: September 18, 2023
Revised: September 28, 2023
Accepted: November 25, 2023
Article in press: November 25, 2023
Published online: December 15, 2023
Core Tip
Core Tip: This study reveals the potential of facilitates fibroblast growth factor 21 (FGF21) in improving pancreatic and intestinal damage recovery, reducing blood glucose levels, and reshaping gut microbiota composition in diabetic mice with acute pancreatitis (AP). Notably, the protective effects of FGF21 are augmented when combined with the Abx cocktail. These findings provide new insights into the prevention and treatment of diabetes complicated by AP.