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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2023; 14(12): 1766-1783
Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1766
Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1766
Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations
Ling-Tong Tang, Lei Feng, Hui-Ying Cao, Yan-Mei Liu, Jian Zhang, Shuang-Yue Li, Department of Clinical Laboratory, Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, Yunnan Province, China
Rui Shi, Bei-Bei Luo, Yan-Bi Zhang, Department of Clinical Laboratory, Sixth Affiliated Hospital of Kunming Medical University, Kunming 650051, Yunnan Province, China
Author contributions: Tang LT and Feng L contributed equally to this work; Tang LT and Feng L drafted the manuscript; Shi R contributed to recruiting patients; Tang LT, Cao HY, and Li SY collected the data; Zhang YB and Zhang J analyzed and interpreted the data; Liu YM contributed to conception and design; Luo BB contributed to administrative support; and all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China , No. 82160402 ; Special Fund for Training Leading Medical Talents in Yunnan Province , China, No. L-2019022.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Sixth Affiliated Hospital of Kunming Medical University (2023-kmykdx6f-66).
Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Feng, PhD, Chief Doctor, Full Professor, Department of Clinical Laboratory, Yan’an Hospital Affiliated to Kunming Medical University, No. 245 Renmin East Road, Kunming 650051, Yunnan Province, China. fngj2004@163.com
Received: October 7, 2023
Peer-review started: October 7, 2023
First decision: October 17, 2023
Revised: October 24, 2023
Accepted: November 17, 2023
Article in press: November 17, 2023
Published online: December 15, 2023
Peer-review started: October 7, 2023
First decision: October 17, 2023
Revised: October 24, 2023
Accepted: November 17, 2023
Article in press: November 17, 2023
Published online: December 15, 2023
Core Tip
Core Tip: This study revealed that gut microbiota in the Han population is significantly different from the Dai population in healthy children, healthy adults, and patients with type 2 diabetes mellitus (T2DM). There was a significant difference in gut microbiota between healthy children and healthy adults in the Han population, but the difference was less in the Dai population. A significant increase in Bacteroidetes was observed in T2DM patients in the Han population, while a significant increase in Proteobacteria was observed in T2DM patients in the Dai population when compared to healthy controls.