Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2021; 12(9): 1363-1385
Published online Sep 15, 2021. doi: 10.4239/wjd.v12.i9.1363
Conundrum of vitamin D on glucose and fuel homeostasis
Maria Mercedes Chang Villacreses, Rudruidee Karnchanasorn, Panadeekarn Panjawatanan, Horng-Yih Ou, Ken C Chiu
Maria Mercedes Chang Villacreses, Panadeekarn Panjawatanan, Ken C Chiu, Department of Clinical Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, Duarte, CA 91010, United States
Maria Mercedes Chang Villacreses, Ken C Chiu, Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90509, United States
Rudruidee Karnchanasorn, Division of Endocrinology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, United States
Panadeekarn Panjawatanan, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States
Horng-Yih Ou, Department of Internal Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 700, Taiwan
Author contributions: Chang Villacreses MM, Chiu KC, Karnchanasorn R, and Ou HY developed the central theme and concepts of this manuscript; Panjawatanan P collected the data and participated in data analyses with Chang Villacreses MM, Chiu KC, Karnchanasorn R, and Ou HY; Chang Villacreses MM and Chiu KC prepared the first draft of manuscript; Chang Villacreses MM, Chiu KC, Karnchanasorn R, and Ou HY took part in critical review and revision of manuscript.
Conflict-of-interest statement: Authors declare no conflict-of-interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ken C Chiu, FACE, FACP, MD, Professor, Department of Clinical Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, United States. kenchiumd@gmail.com
Received: January 26, 2021
Peer-review started: January 26, 2021
First decision: May 3, 2021
Revised: May 10, 2021
Accepted: August 5, 2021
Article in press: August 5, 2021
Published online: September 15, 2021
Core Tip

Core Tip: Vitamin D deficiency is a well-recognized health issue and contributes to bone loss and calcium dysregulation. Evidence suggests that excess vitamin D is not in and of itself of therapeutic benefit. Available clinical data suggests that vitamin D supplementation appears to limit the development of diabetes in vitamin D deficient subjects. However, no benefit was observed in non-vitamin D deficient subjects. Furthermore, overreplacement of vitamin D is of no beneficial effect and could possibly be harmful.