Published online Feb 15, 2024. doi: 10.4239/wjd.v15.i2.240
Peer-review started: October 13, 2023
First decision: November 23, 2023
Revised: December 20, 2023
Accepted: January 22, 2024
Article in press: January 22, 2024
Published online: February 15, 2024
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, the global burden of which is rising. It is still unclear the extent to which prediabetes contributes to the risk of CVD in various age brackets among adults.
To develop a focused screening plan and treatment for Chinese adults with prediabetes, it is crucial to identify variations in the connection between prediabetes and the risk of CVD based on age.
To examine the clinical features of prediabetes and identify risk factors for CVD in different age groups in China.
We analyzed age-specific differences in prediabetes to identify features for the 10-year risk of CVD in a large, representative population divided by age (younger < 40 and older > 40 years old). Chinese atherosclerotic CVD risk prediction model was employed to evaluate the risk of developing CVD over 10 years. Random forest was established in both age groups. SHapley Additive exPlanation method prioritized the importance of features from the perspective of assessment contribution.
In total, 6948 people were diagnosed with prediabetes in this study. In prediabetes, prevalences of CVD were 5 (0.29%) in the younger group and 148 (2.85%) in the older group. Overall, 11.11% of the younger group and 29.59% of the older group were intermediate/high-risk of CVD for prediabetes without CVD based on the China-PAR equation in ten years. In the younger age group, the 10-year risk of CVD was found to be more closely linked to family history of CVD rather than lifestyle, whereas in the older age group, resident status was more closely linked.
The susceptibility to CVD is age-specific in newly diagnosed prediabetes. It is necessary to develop targeted approaches for the prevention and management of CVD in adults across various age brackets.
Identification of prediabetes may help develop strategies to prevent and control CVD in China.