Pourkhalili N, Hosseini A, Nili-Ahmadabadi A, Hassani S, Pakzad M, Baeeri M, Mohammadirad A, Abdollahi M. Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats. World J Diabetes 2011; 2(11): 204-210 [PMID: 22087357 DOI: 10.4239/wjd.v2.i11.204]
Corresponding Author of This Article
Mohammad Abdollahi, Professor, Faculty of Pharmacy, Pharmaceutical Sciences Research Center; Endocrinology and Metabolism Research Institute, Tehran University of Medical sciences, Tehran 1417614411, Iran. mohammad@tums.ac.ir
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World J Diabetes. Nov 15, 2011; 2(11): 204-210 Published online Nov 15, 2011. doi: 10.4239/wjd.v2.i11.204
Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats
Nazila Pourkhalili, Asieh Hosseini, Amir Nili-Ahmadabadi, Shokoufeh Hassani, Mohsen Pakzad, Maryam Baeeri, Azadeh Mohammadirad, Mohammad Abdollahi
Nazila Pourkhalili, Amir Nili-Ahmadabadi, Shokoufeh Hassani, Mohsen Pakzad, Maryam Baeeri, Azadeh Mohammadirad, Mohammad Abdollahi, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical sciences, Tehran 1417614411, Iran
Asieh Hosseini, Razi Institute for Drug Research, Faculty of Medicine, Tehran University of Medical Sciences, Tehran 1417614411, Iran
Author contributions: Pourkhalili N researched the literature and carried out in vivo and in vitro parts of the work and prepared the results; Hosseini A searched the literature, checked results and drafted the manuscript; Nili-Ahmadabadi A performed in vivo and in vitro parts of the study; Hassani S helped in analyzing some of the biochemical parameters; Pakzad M assisted with the in vivo part of the study; Baeeri M carried out the biochemical analysis; Mohammadirad A compiled the literature bibliography, wrote the project and performed statistical analysis; Abdollahi M conceived the study, supervised/reviewed the entire study and edited the manuscript.
Supported by a grant from Tehran University of Medical Science, No. 11250 (in part)
Correspondence to: Mohammad Abdollahi, Professor, Faculty of Pharmacy, Pharmaceutical Sciences Research Center; Endocrinology and Metabolism Research Institute, Tehran University of Medical sciences, Tehran 1417614411, Iran. mohammad@tums.ac.ir
Telephone: +98-21-66959104 Fax: +98-21-66959104
Received: August 24, 2011 Revised: October 26, 2011 Accepted: October 31, 2011 Published online: November 15, 2011
Abstract
AIM: To study the combinative effects of nanocerium and selenium in a murine model of diabetes.
METHODS: Cerium oxide (CeO2) nanoparticles (60 mg/kg per day) and sodium selenite (5 μmol/kg per day) alone or in combination, or the metal form of CeO2 (60 mg/kg) were administered for 2 wk by intraperitoneal injection to streptozotocin-induced diabetic rats. At the end of treatment blood was collected, liver tissue dissected and then oxidative stress markers, extent of energy depletion and lipid profile were evaluated.
RESULTS: Antioxidant enzymes and high density lipoprotein decreased whereas oxidative stress, adenosine diphosphate/adenosine triphospahte levels, cholesterol, triglyceride and low density lipoprotein increased on induction of diabetes. All were improved by a combination of nanocerium and sodium selenite. There was a relative amelioration by CeO2 nanoparticles or sodium selenite alone, but the metal form of CeO2 showed no significant improvement.
CONCLUSION: The combination of nanocerium and sodium selenite is more effective than either alone in improving diabetes-induced oxidative stress.
