González I, Lindner C, Schneider I, Diaz E, Morales MA, Rojas A. Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus. World J Diabetes 2024; 15(2): 154-169 [PMID: 38464365 DOI: 10.4239/wjd.v15.i2.154]
Corresponding Author of This Article
Armando Rojas, PhD, Full Professor, Senior Researcher, Biomedical Research Laboratories, Faculty of Medicine, Catholic University of Maule, 3605 San Miguel Ave, Talca 34600000, Chile. arojasr@ucm.cl
Research Domain of This Article
Nutrition & Dietetics
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Feb 15, 2024; 15(2): 154-169 Published online Feb 15, 2024. doi: 10.4239/wjd.v15.i2.154
Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus
Ileana González, Cristian Lindner, Ivan Schneider, Erik Diaz, Miguel Angel Morales, Armando Rojas
Ileana González, Armando Rojas, Biomedical Research Laboratories, Faculty of Medicine, Catholic University of Maule, Talca 34600000, Chile
Cristian Lindner, Department of Radiology, Faculty of Medicine, University of Concepción, Concepción 4030000, Chile
Ivan Schneider, Centre of Primary Attention, South Metropolitan Health Service, Santiago 3830000, Chile
Erik Diaz, Faculty of Medicine, Catholic University of Maule, Talca 3460000, Chile
Miguel Angel Morales, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago 8320000, Chile
Author contributions: González I, Morales MA, and Rojas A contributed to the conceptualization of this study; González I, Lindner C, Schneider I, Diaz E, Morales MA, and Rojas A participated in the writing-original draft preparation; González I, Morales MA, and Rojas A were involved in the writing-review and editing; and all authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Armando Rojas, PhD, Full Professor, Senior Researcher, Biomedical Research Laboratories, Faculty of Medicine, Catholic University of Maule, 3605 San Miguel Ave, Talca 34600000, Chile. arojasr@ucm.cl
Received: November 5, 2023 Peer-review started: November 5, 2023 First decision: December 6, 2023 Revised: December 16, 2023 Accepted: January 19, 2024 Article in press: January 19, 2024 Published online: February 15, 2024
Abstract
Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with a considerable impact on human life, long-term health expenditures, and substantial health losses. In this context, the use of dietary polyphenols to prevent and manage T2DM is widely documented. These dietary compounds exert their beneficial effects through several actions, including the protection of pancreatic islet β-cell, the antioxidant capacities of these molecules, their effects on insulin secretion and actions, the regulation of intestinal microbiota, and their contribution to ameliorate diabetic complications, particularly those of vascular origin. In the present review, we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.
Core Tip: At present, a compelling body of evidence suggests that dietary polyphenols may represent an important alternative source to the management of type 2 diabetes mellitus due to their multifaceted actions on glucose homeostasis as well as in attenuating many diabetes complications raised because of the hyperglycemic condition. Additionally, new data derived from either clinical trials or meta-analyses have started to figure out the usefulness of these bioactive compounds thus providing solid clinical shreds of evidence.
