Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells

doi:10.4251/wjgo.v16.i2.458

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Oncol. Feb 15, 2024; 16(2): 458-474
Published online Feb 15, 2024. doi: 10.4251/wjgo.v16.i2.458

Table 1 Sequences of primers used in this study

Name	Primer sequence (5’ to 3’)
ZNF710-AS1-201-F	ACCGCAGGCACTTTGAAGA
ZNF710-AS1-201-R	AAGGGACATCAGAGGGGAG
Bcl-2-F	GGTGGGGTCATGTGTGTGG
Bcl-2-R	CGGTTCAGGTACTCAGTCATCC
Bax-F	CCCGAGAGGTCTTTTTCCGAG
Bax-R	CCAGCCCATGATGGTTCTGAT
ZNF710-F	AACAGGAGGTCTATGAGGTTTCT
ZNF710-R	CGCTGAGGTCGATCATCTTGA
IDH2-F	CGCCACTATGCCGACAAAAG
IDH2-R	ACTGCCAGATAATACGGGTCA
SEMA4B-F	GAGCGGCCATTCCTCAGATTC
SEMA4B-R	CACCCACGTACAGGGTCCT
ARHGAP10-F	CCCAGCGGAAGTTTGCTCAT
ARHGAP10-R	ACAGCTCCAAGTTGCTCTTTTC
RGMB-F	CCAGCCCAATGTCGAATCCA
RGMB-R	GGTCACTGATACCCAACACGG
miR-93-5p-F	CGCAAAGTGCTGTTCGTGC
miR-93-5p-R	AGTGCAGGGTCCGAGGTATT
ZNF710-AS1-202-F	GTCCGATCACAGTTCACTAC
ZNF710-AS1-202-R	ATACCAAACCAGGCAACATA

ZNF710: Zinc finger protein 710; IDH2: Isocitrate dehydrogenase-2; SEMA4B: Semaphorin 4B.

Table 2 Comparison of the clinical features of patients between the low- and high-expression groups, mean ± SD

Features	ZNF710-AS1-201		P value
Features	Low expression (n = 34)	High expression (n = 34)	P value
Age, yr	65.62 ± 6.85	67.85 ± 8.25	0.228
Sex, male (%)	19 (55.9)	22 (64.7)	0.457
CEA, U/mL	18.32 ± 69.96	11.09 ± 24.58	0.415¹
Neutrophil count, × 10⁹/L	3.56 ± 0.97	4.67 ± 2.08	0.006¹^,^a
Lymphocyte count, × 10⁹/L	1.89 ± 0.62	1.42 ± 0.47	< 0.001^a
Monocyte count, × 10⁹/L	0.38 ± 0.18	0.44 ± 0.24	0.240
Differentiation degree, III-IV (%)	18 (52.9)	26 (76.5)	0.042^a
T stage, III-IV (%)	15 (44.1)	28 (82.4)	0.001^a
Lymphatic invasion, positive (%)	15 (44.1)	24 (70.6)	0.044^a

^aP < 0.05.

¹Mann-Whitney test.

CEA: Carcinoembryonic antigen; ZNF710: Zinc finger protein 710.

Citation: Ding W, Chen WW, Wang YQ, Xu XZ, Wang YB, Yan YM, Tan YL. Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells. World J Gastrointest Oncol 2024; 16(2): 458-474
URL: https://www.wjgnet.com/1948-5204/full/v16/i2/458.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i2.458