Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype

Table 1 Comparison of pathological features by CpG island methylator phenotype status

	CIMP-H	CIMP-I	CIMP-L	P value
Mean age	66	69.2	63.9
Sex
Female	5	14	28
Male	16	26	71
ypT stage
0 or pCR	2	2	16
1	3	1	7
2	2	10	20
3	11	24	48
4	3	3	8
ypN stage
0	11	27	65
1	6	8	21
2	4	5	13
Systemic recurrence
Absent	14	30	66
Present	5	2	22
Local recurrence
Absent	20	37	87
Present	0	2	6
EMVI
Negative	13	33	84
Positive	8	7	15	CIMP-L vs CIMP-H P = 0.028
KRAS status
Wildtype	15	20	73
Mutant	6	20	26	KRAS Mut + CIMP-I P = 0.01
CRM
Not involved	21	39	95
Involved	0	0	4
RC path score
1 (pCR)	0	2	12
2	6	9	14
3	15	29	73
Total	21	40	99

CRM: Circumferential resection margin; CIMP: CpG island methylator phenotype; EMVI: Extramural vascular invasion; pCR: Pathological complete response.