Laparoscopic vs open complete mesocolic excision with central vascular ligation for colon cancer: A systematic review and meta-analysis

Table 1 Characteristics of the included studies

Ref.	Country of origin	Study type	Study period	Female(number, L/O)	Mean age (yr, L/O)	Intervention (L-CME) right/transverse/left location of the tumor	Control (O-CME) right/transverse/left location of the tumor	Adjuvant chemotherapy
Kim et al[23], 2016	South Korea	Case control, unicentre, prospective database	2008-2013	62/44	69/67	116/0/0	99/0/0	L-CME = 68 pts (58.62%), O-CME = 78 pts (78.78%), recommended to all stage II and III
Storli et al[22], 2016	Norway	Prospective non RT, unicentre	2007-2014	22/13	73/23	0/33/0	0/23/0	L-CME = 8 (61.5%), O-CME = 5 (62.5%), all stage III below 75 yr
Huang et al[24], 2015	China	Case control, unicentre	2012-2013	20/21	56/55	53/0/0	49/0/0	NR
Yamamoto et al[20], 2014	Japan	RCT, multicentre	2004-2009	248/215	64/64	144/0/389	156/0/368	NR, recommended for all stage III
Munkedal et al[25], 2014	Denmark	Prospective nonRT, unicentre	2008-2011	30/38	69.1/72.9	30/0/53	41/0/38	NR
Bae et al[27], 2014	South Korea	Case control, unicentre	2006-2008	40/38	64/65	73/12/0	76/9/0	All stage III and II with poor prognosis
Han et al[26], 2014	China	Case control, unicentre	2003-2010	94/67	67/65	177/0/0	147/0/0	NR, recommended for high risk stage II and stage III
Zhao et al[28], 2014	China	Case control, multicentre	2000-2009	53/44	61.3/64.5	89/30/0	65/36/0	NR, recommended for high risk stage II and stage III
Cong et al[29], 2014	China	Case control, unicentre	2008-2011	53/45	61.5/62.3	96/0/0	82/0/0	NR
Storli et al[30], 2013	Norway	Prospective nonRT, unicentre	2007-2010	49/60	71.9/73.1	50/18/60 2 pts - multiple	35/44/42	All stage III below 75 yr
Gouvas et al[31], 2012	Greece	Prospective nonRT, multicentric	2006-2010	19/17	62.1/66.3	7/9/33	9/9/23	NR
Sun et al[32], 2012	China	Case control, unicentre	2000-2008	58/45	60.1/61.9	49/7/91	43/9/74	NR, according to stage

L-CME: Laparoscopic complete mesocolic excision; O-CME: Open complete mesocolic excision; RT: Randomized control trial; Non RT: Non randomized control trial; L/O: Laparoscopy/open groups; NR: Not reported.