Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study

Table 4 Cox multivariate analysis for disease specific survival

	N0		N+
	HR	95%CI	HR	95%CI
Age
< 70 yr	1.00	Ref.	1.00	Ref.
> 70 yr	0.47	0.16-1.40	1.19	0.53-2.67
pT-status
T1	1.00	Ref.	1.00	Ref.
T2	0.12	0.01-1.29	0.48	0.06-3.50
T3	0.69	0.08-6.25	1.29	0.27-6.07
T4	0.46	0.02-8.70	1
Grading
Poor	1.00	Ref.	1.00	Ref.
Moderate	1.03	0.20-5.30	0.46	0.21-1.04
Well	1		1
Adjuvant treatment
No	1.00	Ref.	1.00	Ref.
Yes	0.2	0.01-2.57	1.04	0.32-3.41
TSR
TSR-high	1.00	Ref.	1.00	Ref.
TSR-intermediate	5.27a	1.54-18.1	1.60	0.54-4.70
TSR-low	3.48	0.78-15.55	1.22	0.41-3.66

^aP < 0.05;

¹Too small numbers to analyze. Age defined as period from birth until date of primary surgery. N0: Lymph node metastasis negative patients; N+: Lymph node metastasis positive patients; pT: Pathological tumor status; TSR: Tumor-stroma ratio.