Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study

Table 3 Cox multivariate analysis for disease free survival

	N0		N+
	HR	95%CI	HR	95%CI
Age
< 70 yr	1.00	Ref.	1.00	Ref.
> 70 yr	0.36	0.13-1.01	0.89	0.36-2.22
pT-status
T1	1.00	Ref.	1.00	Ref.
T2	0.11	0.01-1.21	0.66	0.10-4.44
T3	0.85	0.09-7.58	1.51	0.31-7.30
T4	1.61	0.07-39.27	1
Grading
Poor	1.00	Ref.	1.00	Ref.
Moderate	1.43	0.29-6.99	0.58	0.25-1.35
Well	1		1
Adjuvant treatment
No	1.00	Ref.	1.00	Ref.
Yes	0.2	0.01-2.57	1.04	0.32-3.41
TSR
TSR-high	1.00	Ref.	1.00	Ref.
TSR-intermediate	6.41a	1.84-22.28	1.31	0.49-3.51
TSR-low	3.7	0.84-16.42	0.93	0.31-2.74

^aP < 0.05;

¹Too small numbers to analyze. Age defined as period from birth until date of primary surgery. N0: Lymph node metastasis negative patients; N+: Lymph node metastasis positive patients; pT: Pathological tumor status; TSR: Tumor-stroma ratio.