Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study

Table 2 Cox multivariate analysis for overall survival

	N0		N+
	HR	95%CI	HR	95%CI
Age
< 70 yr	1	Ref.	1	Ref.
> 70 yr	3.32a	1.75-6.28	2.26a	1.10-4.65
Grading
Poor	1	Ref.	1	Ref.
Moderate	1.03	0.43-2.49	0.52	0.25-1.10
Well	0.36	0.04-2.99	0.56	0.06-5.31
Adjuvant treatment
No	1	Ref.	1	Ref.
Yes	0.47	0.06-3.50	0.66	0.27-1.60
TSR
TSR-high	1	Ref.	1	Ref.
TSR-intermediate	2.04	0.99-4.21	1.19	0.50-2.84
TSR-low	1.43	0.57-3.60	1.04	0.40-2.69

^aP < 0.05. Age defined as period from birth until date of primary surgery. N0: Lymph node metastasis negative patients; N+: Lymph node metastasis positive patients; TSR: Tumor-stroma ratio.