MicroRNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6

Table 1 The top 10 miRNA changes between colorectal adenoma and carcinoma

	Systematic name	Expression levels vs normal (mean ± SD)		P value
		Adenoma	Carcinoma
Laterally spreading types (n = 3)
1	hsa-miR-320b	0.649 ± 0.170	0.402 ± 0.146	0.00488
2	hsa-miR-320e	0.666 ± 0.159	0.376 ± 0.085	0.0213
3	hsa-miR-937-5p	0.842 ± 0.169	1.446 ± 0.253	0.0215
4	hsa-miR-574-5p	1.287 ± 0.477	0.881 ± 0.339	0.0373
5	hsa-miR-320d	0.705 ± 0.204	0.425 ± 0.108	0.0407
6	hsa-miR-320a	0.645 ± 0.140	0.412 ± 0.198	0.0417
7	hsa-miR-26b-5p	1.751 ± 0.307	1.003 ± 0.600	0.0477
8	hsa-miR-320c	0.676 ± 0.181	0.401 ± 0.072	0.0516
9	hsa-miR-361-5p	1.976 ± 0.124	1.469 ± 0.378	0.0762
10	hsa-miR-195-5p	0.729 ± 0.172	0.391 ± 0.338	0.0772
Protruded tumors (n = 3)
1	hsa-miR-320d	1.450 ± 0.388	0.805 ± 0.369	0.000284
2	hsa-miR-320b	1.456 ± 0.386	0.834 ± 0.362	0.00203
3	hsa-miR-375	1.312 ± 0.163	0.285 ± 0.174	0.00492
4	hsa-miR-320e	1.350 ± 0.278	0.772 ± 0.362	0.00724
5	hsa-miR-320c	0.879 ± 0.236	0.584 ± 0.219	0.0105
6	hsa-miR-320a	1.262 ± 0.208	0.810 ± 0.263	0.0110
7	hsa-miR-663a	0.985 ± 0.786	1.317 ± 0.798	0.0114
8	hsa-miR-211-3p	1.634 ± 0.193	1.533 ± 0.189	0.0129
9	hsa-miR-378i	1.110 ± 0.223	0.640 ± 0.333	0.0250
10	hsa-miR-26b-5p	1.261 ± 0.462	0.896 ± 0.360	0.0253