Role of Raman spectroscopy and surface enhanced Raman spectroscopy in colorectal cancer

doi:10.4251/wjgo.v8.i5.427

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May 15, 2016 (publication date) through May 2, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. May 15, 2016; 8(5): 427-438
Published online May 15, 2016. doi: 10.4251/wjgo.v8.i5.427

Table 1 A comparison of Raman spectroscopy, fourier transform infrared spectroscopy and hematoxylin and eosin staining strengths and weaknesses

	Raman spectroscopy	FTIR	Hematoxylin and eosin staining
Method of detection	Inelastic scattering of monochromatic (laser) light	Absorbance (polychromatic light source)	Combination of basic and acidic dyes
Real time	Yes	Yes	No
Wavenumber range (cm^-1)	50-4000	400-4000	N/A
Spatial resolution	1 μm	5 μm	Cellular
Enhancement techniques	SERS, TERS, CARS, SORS, SRS	ATR	"Special" staining
Effect of water	Minimal	Large absorbance in NIR region	No
Destructive to sample	No	No	Yes

SERS: Surface enhanced Raman spectroscopy; TERS: Tip enhanced Raman spectroscopy; CARS: Coherent anti-Stokes Raman spectroscopy; SORS: Spatially offset Raman spectroscopy; SRS: Stimulated Raman spectroscopy; ATR: Attenuated total reflection; FTIR: Fourier transform infrared spectroscopy; NIR: Near-infrared; N/A: Not available.

Citation: Jenkins CA, Lewis PD, Dunstan PR, Harris DA. Role of Raman spectroscopy and surface enhanced Raman spectroscopy in colorectal cancer. World J Gastrointest Oncol 2016; 8(5): 427-438
URL: https://www.wjgnet.com/1948-5204/full/v8/i5/427.htm
DOI: https://dx.doi.org/10.4251/wjgo.v8.i5.427