Status of colitis-associated cancer in ulcerative colitis

Table 1 A comparison colitis-associated cancer and sporadic colorectal cancer

CAC: Up to 20% of UC patients develop CAC within 30 yr of disease onset

CAC: High overall mortality rate

NSAID use reduces the risk of CRC, suggesting a potential role for anticytokine therapy

CRC: Classic adenoma to carcinoma sequence

CAC: Chronic inflammation, injury, dysplasia, and CRC

The common genetic and signaling pathways are different between

CRC and CAC including β-catenin, p53, k-ras, B-raf

Both CRC and CAC are associated with transcription factors, such as

NF-κB and/or STAT3 which mediate the immune response and oncogenesis

Both CRC and CAC depend on the quality and quantity of intestinal microflora

CRC: Colorectal cancer; CAC: Colitis-associated cancer; UC: Ulcerative colitis; NSAID: Nonsteroidal anti-inflammatory drug; NF-κB: Nuclear factor-κB; STAT3: Signal transducer and active of transcription 3.