Is metastatic pancreatic cancer an untargetable malignancy?

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Mar 15, 2016; 8(3): 297-304
Published online Mar 15, 2016. doi: 10.4251/wjgo.v8.i3.297

Table 2 Clinical trials in metastatic pancreatic cancer associating two targeted therapies to chemotherapeutical agents

Ref.	Regimen	Phase	PFS	OS
Van Cutsem et al[18]	Gemcitabine/erlotinib/bevacizumab Gemcitabine/erlotinib	III	4.6	7.1
Van Cutsem et al[18]	Gemcitabine/erlotinib/bevacizumab Gemcitabine/erlotinib	III	3.6	6.0
Philip et al[19]	Gemcitabine/erlotinib/cixutumumab Gemcitabine/erlotinib	I	3.6	7.0
Philip et al[19]	Gemcitabine/erlotinib/cixutumumab Gemcitabine/erlotinib	I	3.6	6.7
Watkins et al[20]	Gemcitabine/capecitabine/erlotinib/bevacizumab	I/II	8.4	12.6
NCT02450656 (ongoing trial)	Afatinib/selumetinib	II	NA	NA
NCT02450656 (ongoing trial)	Capecitabine	II	NA	NA

PFS: Progression free survival; OS: Overall survival; NA: Not available.

Citation: Kourie HR, Gharios J, Elkarak F, Antoun J, Ghosn M. Is metastatic pancreatic cancer an untargetable malignancy? World J Gastrointest Oncol 2016; 8(3): 297-304
URL: https://www.wjgnet.com/1948-5204/full/v8/i3/297.htm
DOI: https://dx.doi.org/10.4251/wjgo.v8.i3.297

Kourie HR, Gharios J, Elkarak F, Antoun J, Ghosn M. Is metastatic pancreatic cancer an untargetable malignancy? World J Gastrointest Oncol 2016; 8(3): 297-304 [PMID: 26989465 DOI: 10.4251/wjgo.v8.i3.297]

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