Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer

Table 1 MiRNA profile of lynch syndrome patients

MiRNA	Expression status	Function	Ref.
miR-155	Up	MMR deficiency	Valeri et al[46]
		MSI	Earle et al[48]
miR-26b	Down	MSS	Earle et al[48]
miR-31	Up	MSI	Earle et al[48]
miR-223	Up	MSI	Earle et al[48]
miR-486-5p	Down	MSI	Balaguer et al[47]
miR-622	Up	MSI	Balaguer et al[47]
miR-1238	Up	MSI	Balaguer et al[47]
miR-1362-5p	Down	MSI	Balaguer et al[47]
miR-132	Down	MMR deficiency	Kaur et al[49]
miR-345	Down	MMR deficiency	Kaur et al[49]

MSS: Microsatellite stabile; MSI: Microsatellite instability; MMR: Mismatch repair.