Role of microRNA-7 in digestive system malignancy

Table 1 Expression of microRNA-7 in the digestive system

Cancer	Sample	Sap No.	Method	Exp	Role	Ref.
Colon	Stool	60	qPCR	↑	Diagnostic	[27]
CRC	Tissue	80	qPCR	↓	Diagnostic/therapeutic	[21]
CRC	Tissue	8	RT-PCR	↓	Therapeutic	[22]
CRC	Tissue	105	qRT-PCR	↑	Prognostic	[26]
ESCC	Tissue	34	Microarray/qRT-PCR	↑	Differentiation	[29]
GC	Tissue	40	ISH/IHC	↓	Inhibits metastasis/EMT	[18]
GC	Tissue	23	Microarray	↓	Inhibits invasion/metastasis	[19]
			qRT-PCR
GC	Tissue	28	RT-PCR	↓	Represses inflammation	[20]
HCC	Tissue	10	Microarray	-	Therapeutic/diagnostic/prognostic	[28]
			qRT-PCR
HCC	Tissue	12	qRT-PCR	↓	Tumor suppressor	[23]
HCC	Tissue	429	Chip assay	↓	Prognostic	[43]
CD	Tissue	-	RT-PCR	↓	Therapeutic	[25]

↓: MiR-7 is downregulated; ↑: MiR-7 is upregulated; −: There is no alteration for expression of miR-7, or no mention. Sap No.: Sample number; Exp: Expression; ISH/IHC: In situ hybridization/immunohistochemistry; CRC: Colorectal cancer; GC: Gastric cancer; HCC: Hepatocellular carcinoma; ESCC: Esophageal squamous cell carcinoma; EMT: Epithelial–mesenchymal transition; qPCR: Quantitative polymerase chain reaction.