Epigenetic reduction of DNA repair in progression to gastrointestinal cancer

Table 6 Median mutation frequencies and ranges

Parent/child per generation orcancer type	Mutation frequency per million bases	Mutation frequency per diploid genome
Parent/child per generation	0.00000023	30-70
Colorectal carcinoma	Approximately 5	Approximately 30000
MSS colon cancer	2.8	16800
MSI colon cancer (mismatch DNA repair deficient)	47	282000
Hepatocellular carcinoma	4.2	25200
Esophageal carcinoma (single nucleotide variants)	2.8	16994
	Range 0.7-9.3	Range 4516-56528
Esophageal carcinoma (small insertions and deletions)		994 Range 262-3573

MSS: Microsatellite stable; MSI: Microsatellite instable.