Epigenetic reduction of DNA repair in progression to gastrointestinal cancer

doi:10.4251/wjgo.v7.i5.30

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May 15, 2015 (publication date) through Apr 24, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. May 15, 2015; 7(5): 30-46
Published online May 15, 2015. doi: 10.4251/wjgo.v7.i5.30

Table 2 Endogenous DNA damages/cell/day for humans

DNA damages	Reported rate of occurrence
Oxidative damages	10000[24]
Depurinations	9000[25]
Depyrimidations	696[26]
Single-strand breaks	55000[26]
Double-strand breaks	Approximately 50/cell cycle[27]
O⁶-methylguanine	3120[26]
Cytosine deamination	192[26]

Citation: Bernstein C, Bernstein H. Epigenetic reduction of DNA repair in progression to gastrointestinal cancer. World J Gastrointest Oncol 2015; 7(5): 30-46
URL: https://www.wjgnet.com/1948-5204/full/v7/i5/30.htm
DOI: https://dx.doi.org/10.4251/wjgo.v7.i5.30