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©The Author(s) 2015.
World J Gastrointest Oncol. Nov 15, 2015; 7(11): 285-291
Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.285
Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.285
Table 1 Phase I studies on intraperitoneal chemotherapy using taxanes for the treatment of gastric cancer with peritoneal carcinomatosis
| Ref. | n | Intraperitoneally administered taxanes | Initial dose(mg/m2) | MTD(mg/m2) | RD(mg/m2) | DLT |
| Kodera et al[42] | 4 | PTX | 60 | - | - | - |
| Fushida et al[26] | 24 | DOC | 25 | 60 | 45 | Abdominal pain and |
| diarrhea | ||||||
| Ishigami et al[45] | 9 | PTX | 20 | 30 | 20 | Febrile neutropenia and diarrhea |
| Fujiwara et al[43] | 12 | DOC | 40 | - | 60 | - |
| Kurita et al[44] | 18 | PTX | 40 | 90 | 80 | Leukocytopenia |
| Fushida et al[16] | 12 | DOC | 35 | 50 | 45 | Febrile neutropenia and diarrhea |
- Citation: Yamaguchi H, Kitayama J, Ishigami H, Kazama S, Nozawa H, Kawai K, Hata K, Kiyomatsu T, Tanaka T, Tanaka J, Nishikawa T, Otani K, Yasuda K, Ishihara S, Sunami E, Watanabe T. Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes. World J Gastrointest Oncol 2015; 7(11): 285-291
- URL: https://www.wjgnet.com/1948-5204/full/v7/i11/285.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v7.i11.285