Primary tumor resection in colorectal cancer with unresectable synchronous metastases: A review

Table 3 Prognostic factors after primary tumor resection on multivariate analyzes

Ref.	Metastatic spread	No. of patients	Prognostic factors or predictive factors of postoperative morbimortality
Rosen et al[43]	Liver, Peritoneum	125	Age < 65 yr, limited LM, no peritoneal carcinomatosis
Ruo et al[44]	Liver, peritoneum, retroperitoneal lymph nodes, lung, bone, brain	123	Liver involvement < 25%
Stelzner et al[45]	Mainly liver	186	WHO-PS, ASA grade, low CEA level, metastatic load, chemotherapy
Vibert et al[47]	Liver	80	Serum AST level < 50 IU/l, age < 75 yr
Yun et al[37]	Liver, peritoneum, lung	503	CEA level, well-differentiated primary tumor, chemotherapy
Kleespies et al[46]	Mainly liver, lung, peritoneum	233	Liver involvement < 50%, chemotherapy, pT4 and/or N+ stage
Costi et al[48]	Mainly liver, peritoneum	71	Age < 80 yr, nodal stage
Stillwell et al[31]	Liver and extra-hepatic	379	Nodal stage < N2, well-differentiated primary tumor, no postoperative complications, no apical lymph-node

LM: Liver metastases; ASA: American society of anesthesiology; CEA: Carcinoembryonic antigen; WHO-PS: World health organization performance status.