Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer

Table 1 Potential blood microRNA markers

MiRNA	AA?	Ref.
Upregulated in primary CRC
miR-7		[81]
miR-15b	√	[78,80]
miR-17-5p	√	[80]
miR-17-3p		[76,81]
miR-18a	√	[78,79]
miR-19a		[78]
miR-19b		[78]
miR-20a		[79,81]
miR-21		[79,81,83,87,160-163]
miR-29a		[78,79,82]
miR-92a		[76,79,81-83]
miR-96		[81]
miR-106b		[79]
miR-133a		[79]
miR-142-3p	√	[80]
miR-143		[79]
miR-145		[79]
miR-183		[81]
miR-195	√	[80]
miR-196a		[81]
miR-214		[81]
miR-221		[84]
miR-331	√	[80]
miR-335		[78]
miR-532-5p	√	[80]
miR-532-3p	√	[80]
miR-652	√	[80]
miR-1246		[164]
Upregulated in metastatic CRC
miR-15b	√	[80]
miR-29a		[85]
miR-139-3p		[80]
miR-141		[86]
miR-431		[80]
Downregulated in primary CRC
miR-124		[81]
miR-127-3p		[81]
miR-138		[81]
miR-143		[81]
miR-146a		[81]
miR-222		[81]
miR-601	√	[77]
miR-760	√	[77]

AA: Able to differentiate advanced adenoma; CRC: Colorectal cancer; MiRNA: MicroRNA.