Field Of Vision
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastrointest Oncol. Mar 15, 2013; 5(3): 43-49
Published online Mar 15, 2013. doi: 10.4251/wjgo.v5.i3.43
Table 1 Examples of epigenetic alterations (epimutations) of DNA repair genes in colon cancers and in their field defects, with CpG island methylation indicated where known
ReferenceEpimutations in genes found in colon cancer (mechanism)Percentage of the sporadic cancers with that epimutationEpimutations in genes in field defect (mechanism)Percentage of the field defect with that epimutation
Agrelo et al[31]WRN (CGI)38%
Shen et al[32]MGMT (CGI)46%MGMT (CGI)23%
Psofaki et al[33]MGMT (CGI)90%
Psofaki et al[33]MLH1 (CGI)65%
Truninger et al[29]MLH1 (CGI)96%
Lee et al[34]MLH1 (CGI)2%
Lee et al[34]MSH2 (CGI)13%MSH2 (CGI)5%
Lee et al[34]MGMT (CGI)47%MGMT (CGI)11%
Facista et al[35]ERCC1100%ERCC160%
Facista et al[35]PMS288%PMS250%
Facista et al[35]XPF55%XPF40%