Surgery for colorectal liver metastases: The evolution of determining prognosis

Table 3 Studies of prognostic biomarkers

Study	No. of patients	Positive case (%)	Biomarker	Correlation with survival
Nash et al[110]	188	27	KRAS	Independent predictor of poor survival (HR = 1.9)
Nash et al[110]	188	62	Ki-67	Independent predictors of poor survival (HR = 2.6)
Teng et al[113]	292	2.1	BRAF	Independent prognostic biomarker after metastasectomy (HR = 6.245, P < 0.003)
Smith et al[26]	66	36	Ki-67	Ki-67 correlate with survival (P = 0.04)
Smith et al[26]	66	35	hTERT	Htert correlate with survival (P = 0.0001)
Dômont et al[25]	201	43	hTERT	Independent predictor of poor survival
				(RR = 2.03, P < 0.0001)
Gonen et al[123]	156	Not reported	TS	Independent predictor of poor survival
				(RR = 4.22, P < 0.01)
Costa et al[137]	104	Not reported	TLI	High TLI independently
				Predicted decreased DFS
				(P = 0.035)
Nitti et al[128]	69	64	p53	Independent predictor of poor survival
				(RR = 2.53, P = 0.008)
Mehta et al[144]	50	30	FGA	A high FGA is an independent predictor of survival (P = 0.01)
Shimomura et al[136]	64	31	HIF-1α	High HIF-1α is an independent risk factor for recurrence

hTERT: Human telomerase reverse transcriptase; TS: Thymidylate synthase; TLI: Thymidylate labeling index; DFS: Disease free survival; FGA: Fraction of genome altered; HIF-1α: Hypoxia inducible factor-1α.