Clinical importance and surgical decision-making regarding proximal resection margin for gastric cancer

Table 1 Effects of positive margins on survival

Ref.	Inclusion	n	Effect of positive margins on survival
			All patientsP value	Subgroup analysis
				Nodal status	P value
Kim et al[11]	GC	619	< 0.0001	≤ 5 LNI	0.0001
				> 5 LNI	NS
Cascinu et al[19]	AGC	259	Significant	Node negative	0.001
				Node positive	NS
Cho et al[16]	AGC	2740	0.0028	Node negative	0.0001
				Node positive	0.259
Sun et al[16]	GC	2728	< 0.001	N0	< 0.001
				N1	0.007
				N3, N4	NS
Morgagni et al[17]	GC	89	< 0.0001	N0	0.001
				N1	0.003
				N2	0.009
				N4	NS

GC: Gastric cancer; AGC: Advanced gastric cancer; NS: Not significant; LNI: Lymph node involvement.