Leukocyte DNA methylation and colorectal cancer among male smokers

Table 4 Methylation of CpG sites associated with colorectal cancer with short to mediate latency (P value < 0.01 before multiple testing correction)¹

Marker name	2nd tertile vs 1st tertile			3rd tertile vs 1st tertile			P2
	OR	L95	U95	OR	L95	U95
GLA	1.31618	1.12303	1.54256	1.31082	1.09072	1.57534	0.000126734
DSP	1.12406	0.9868	1.2804	1.25115	1.11146	1.4084	0.000305565
B3GALT5	1.00109	0.88664	1.1303	1.18931	1.05066	1.34625	0.001334159
MLH3	1.01719	0.89178	1.16025	1.2404	1.08916	1.41263	0.001421327
PTCH2	1.18044	1.04387	1.33487	1.24209	1.1026	1.39922	0.002140961
FLT4	1.26038	1.1159	1.42356	1.15518	1.01153	1.31924	0.002164413
SGCE	1.05149	0.92678	1.19299	1.19126	1.05786	1.34148	0.002535873
HOXC6	1.02303	0.90426	1.15741	1.16253	1.03342	1.30777	0.002602644
PDE1B	1.19845	1.06385	1.35009	1.10584	0.96046	1.27323	0.002706305
COL18A1	1.2126	1.07142	1.37239	1.19961	1.06058	1.35687	0.002968143
TRPM5	1.16951	1.02324	1.3367	1.10173	0.94879	1.27933	0.003084609
EVI1	1.06179	0.93967	1.19979	0.94512	0.8274	1.07959	0.003902443
GSTM2	1.24009	1.10312	1.39407	1.13952	1.0059	1.29089	0.003956314
FASTK	1.12763	0.99513	1.27778	1.17539	1.04318	1.32436	0.004798386
PARP1	1.08475	0.97053	1.2124	0.87907	0.77119	1.00203	0.005028903
PTGS2	1.03008	0.91145	1.16415	1.15319	1.02574	1.29648	0.00571389
WRN	0.97839	0.8614	1.11128	1.09867	0.96629	1.24918	0.005779497
EPO	1.14731	1.01334	1.299	1.13034	0.9854	1.2966	0.006090622
GPC3	1.19056	1.03981	1.36316	1.09698	0.94341	1.27556	0.006093671
TK1	1.13458	0.98846	1.30232	1.20862	1.05753	1.3813	0.006272625
EVI1	1.14882	1.01559	1.29953	1.17851	1.04142	1.33364	0.006474115
EPHB2	1.15596	1.02875	1.2989	1.05233	0.92701	1.19459	0.006504075
SEMA3C	1.10197	0.98427	1.23375	0.89579	0.7921	1.01304	0.00677389
HLA_DPA1	1.14664	1.00965	1.30223	1.09326	0.95971	1.24538	0.006960326
SYBL1	1.06835	0.9547	1.19553	0.90635	0.80226	1.02394	0.007029222
INSR	1.19021	1.05214	1.34639	1.25474	1.11332	1.41412	0.008045993

¹The logistic regression analysis only includes cases with short and medium latency;

²P from proportional odds regression model (all cases were included).