Leukocyte DNA methylation and colorectal cancer among male smokers

Table 3 Methylation of CpG sites related to colorectal cancer development with different latencies (P value < 0.01 before multiple testing correction)¹

Marker name	2nd tertile vs 1st tertile			3rd tertile vs 1st tertile			P2
	OR	L95	U95	OR	L95	U95
DSP	1.52027	0.91054	2.53831	2.62423	1.65105	4.17103	0.000104474
PTCH2	1.86565	1.14946	3.02807	2.55851	1.60114	4.08832	0.000327688
GLA	3.22896	1.66054	6.27879	3.62345	1.70627	7.69478	0.000529374
FLT4	2.49882	1.55051	4.02713	1.7312	1.02958	2.91095	0.000651567
B3GALT5	0.91735	0.5746	1.46454	2.11128	1.31709	3.38434	0.000726807
INSR	1.88977	1.16281	3.07122	2.44371	1.52713	3.91043	0.0007899
GSTM2	2.29464	1.44903	3.63373	1.92103	1.18011	3.12712	0.001165928
FASTK	1.66117	1.02457	2.69331	2.26999	1.43313	3.59553	0.001992703
MLH3	1.12063	0.67503	1.86036	2.15187	1.31098	3.53213	0.002175877
HOXC6	1.2189	0.75795	1.96015	2.06861	1.32056	3.24043	0.002826542
MGMT	2.42747	1.34114	4.39373	2.71599	1.45027	5.08638	0.00448402
SYBL1	1.35661	0.89446	2.05754	0.63927	0.39971	1.02239	0.004618893
PDE1B	2.12203	1.33959	3.36151	1.74663	1.01704	2.9996	0.004839975
SEMA3C	1.34045	0.87915	2.04378	0.62126	0.38566	1.0008	0.004858838
AFF3	2.11473	1.30773	3.41973	1.88147	1.16588	3.03628	0.005422481
HCK	2.0406	1.27766	3.25911	2.0338	1.19416	3.46382	0.005503
PXN	1.92122	1.24421	2.9666	1.12493	0.66824	1.89374	0.005766585
PARP1	1.19708	0.79209	1.80913	0.55056	0.33191	0.91323	0.006004429
TK1	1.83172	1.07512	3.12075	2.24792	1.34064	3.76922	0.006184503
SGCE	1.21217	0.74619	1.96916	1.9685	1.25257	3.09363	0.006354949
MME	2.00858	1.25423	3.21663	1.94042	1.20308	3.12967	0.00664085
RARA	1.51526	0.94405	2.43209	2.07639	1.31635	3.27525	0.006899358
COL18A1	2.08647	1.28893	3.37752	1.90316	1.17926	3.07144	0.007110996
SEMA3F	1.98588	1.21715	3.24014	2.03976	1.22672	3.39166	0.007292652
ITGB4	2.08685	1.2669	3.43748	2.02919	1.20223	3.42495	0.007595246
PTPRH	0.47922	0.30082	0.76343	0.71909	0.44823	1.15361	0.007598903
SMO	1.52188	0.95276	2.43094	2.08604	1.3032	3.33915	0.008280298
DKC1	1.25326	0.76383	2.05632	2.20393	1.27785	3.80116	0.008427231
TRPM5	2.22962	1.33245	3.73087	1.80604	1.01389	3.21707	0.008971559
EVI1	1.62829	1.01415	2.61431	2.08373	1.29638	3.34927	0.009481166
EPHA3	1.93252	1.21576	3.07185	1.85827	1.15814	2.98165	0.009792546

¹Latency: according to the time difference between blood draw and cancer diagnosis, cases were classified to three categories-short, medium, and long latency;

²P from proportional odds regression model (all cases were included).