HCV infection, B-cell non-Hodgkin’s lymphoma and immunochemotherapy: Evidence and open questions

Table 2 Clinical features and prevalence of hepatitis C virus-positive patients in low grade B-lymphoma series

Author	Year	HCV-positive patients number	Histology	Study type	Clinical features of HCV-positive1
Arcaini et al[19]	2006	49 (15%) out of 309	SMZL	Retrospective series analysis	B-symptoms
					Female prevalence
					Abdominal lymph nodes
					Villous lymphocytes
					Monoclonal component
					Cryoglobulin
Ferreri et al[12]	2006	7 (12%) out of 55	OAL of the MALT type	Retrospective series analysis	Advanced extra-orbital disease
					Lymph node dissemination
					Involvement of other extranodal organs
					Worse progression free survival
Arcaini et al[23]	2007	9 (19%) out of 47	Nodal MZL	Retrospective series analysis	Advanced stage
					B-symptoms
					Cryoglobulin
Arcaini et al[30]	2006	60 (35%) out of 172	Non-gastric MALT	Retrospective series analysis	Single MALT site
					Older age
					Female prevalence
					Less frequent marrow involvement
Strianese et al[24]	2010	23 (18%) out of 129	OAL	Retrospective series analysis	More widespread disease at the onset

¹Clinical features with statistical relevance compared to hepatitis C virus (HCV)-negative patients. OAL: Ocular adnexal lymphoma; MZL: Marginal zone lymphoma; SMZL: Splenic MZL.