Goblet cell carcinoid tumors of the appendix: An overview

Table 2 Treatment guidelines recommended by various authors (1974-2008)

Subbuswamy et al[2]	APX
	RH in case of cecal involvement
Klein[3]	APX
Haqqani et al[40]	RH if base of appendix or caecum is involved
Warkel et al[4]	RH in case of spread beyond appendix, atypia, and mitotic count ≥ 2/10 hpf
Chen et al[41]	APX alone unless there is cecal involvement
Olsson et al[42]	RH in case of spread beyond appendix, atypia, and mitotic count ≥ 2/10 hpf
Edmonds et al[33]	RH in all cases
Bak et al[39]	RH in case of spread beyond appendix, atypia, and mitotic count ≥ 2/10 hpf
Park et al[43]	RH in all cases
Rutledge et al[44]	RH in all cases
Butler et al[36]	RH for cecal involvement, BSO in females
Ramnani et al[13]	< 2 cm in size, without serosal & lymphatic involvement-APX
	More advanced tumor-RH
Kanthan et al[30]	RH
Li et al[31]	RH for N1, M1 or Mib1 > 3%
Varisco et al[23]	RH in case of spread beyond appendix, atypia, and mitotic count ≥ 2/10 hpf
Byrn et al[35]	No value of RH in non-metastatic cases
Pham et al[22]	RH with attendant mesenteric nodal resection for (1) T3/T4 disease or nodal involvement; (2) direct cecal involvement; and (3) clinically positive mesenteric nodes
	Bilateral oophorectomy for post menopausal women
O’Donnell et al[20]	RH irrespective of stage
Tang et al[17]	Group A T1, 2-no recommendations
	T3 or 4, group B/C, perforation, positive margin-RH with oophorectomy if possible. CT in stage III/IV
	Stage IV/group C- debulking/oophorectomy/systemic/intraperitoneal CT

APX: Appendicetomy; RH: Right hemicolectomy; hpf: High power fields; CT: Computed tomography.