Editorial
Copyright ©2010 Baishideng.
World J Gastrointest Oncol. Jun 15, 2010; 2(6): 251-258
Published online Jun 15, 2010. doi: 10.4251/wjgo.v2.i6.251
Table 1 Comparison of clinicopathological features of goblet cell carcinoid, carcinoid & adenocarcinoma
Goblet cell carcinoidCarcinoidAdenocarcinoma
Clinical features
Age5th-6th decade4th decade7th decade
Carcinoid syndromeNoYesNo
Primary symptomsAcute appendicitisAcute appendicitisMass
Gross appearance> 2 cm, ill defined thickening< 2 cm> 2 cm, well defined mass
Microscopic appearance
MorphologyClusters of goblet or signet-ring cells separated by fibrosis/pools of mucinNests of small cellsWell-formed glands to sheets of poorly differentiated signet-ring cells
AtypiaMinimalMinimalMarked
MitosisRareRareIncreased
Vascular and perineural invasionPresentAbsentPresent
Infiltrative marginsPresentAbsentPresent
Special stains
ArgyrophilPositivePositiveUsually negative
ArgentaffinNegativePositiveNegative
Mucicarmine/PAS/PASDPositive in goblet cellsNegativePositive
IHC
CEA+-+
CDX2+-+
CAM5.2+-+
CK20±-+
CK7±--
CK19+--
Neuroendocrine markers±±-
Math1 and HD5+-+
p53, p16--+
Molecular pathology
DPC4, Kras, β-catenin mutation and p53 over expression--+