Pharmacologic rationale for treatments of peritoneal surface malignancy from colorectal cancer

Table 1 Molecular weight and area under the curve ratios of intraperitoneal exposure to systemic exposure of chemotherapeutic agents used to treat peritoneal carcinomatosis

Drug	Molecular weight (Daltons)	Area under the curve ratio
5-fluorouracil	130.08	250
Carboplatin	371.25	10
Cisplatin	300.1	7.8
Docetaxel	861.9	552
Doxorubicin	579.99	230
Etoposide	588.58	65
Floxuridine	246.2	75
Gemcitabine	299.5	500
Irinotecan	677.19	N/A
Melphalan	305.2	93
Mitomycin C	334.3	23.5
Mitoxantrone	517.41	115-255
Oxaliplatin	397.3	16
Paclitaxel	853.9	1000
Pemetrexed	597.49	40.8

N/A: Not available.