Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and systemic immune-inflammation index predict survival in HER2-negative advanced gastric cancer

Table 3 Univariate and multivariate Cox regression analyses of factors influencing overall survival

Variables	Univariate analysis			Multivariate analysis
	β	P value	HR (95%CI)	β	P value	HR (95%CI)
Gender
Male			1.000 (reference)
Female	0.307	0.264	1.359 (0.793-2.330)
Age	0.011	0.402	1.011 (0.985-1.038)
BMI	0.040	0.446	1.040 (0.940-1.152)
Smoking history
Yes			1.000 (reference)
No	0.411	1.132	1.509 (0.883-2.577)
Drinking history
Yes			1.000 (reference)
No	-0.270	0.280	0.764 (0.468-1.245)
Tumour site
Gastric body			1.000 (reference)
Cardia	0.258	0.452	1.294 (0.661-2.533)
Antrum	0.297	0.426	1.346 (0.648-2.800)
Lesser curvature	-0.548	0.251	0.578 (0.226-1.475)
Degree of differentiation
Highly differentiated			1.000 (reference)
Moderately differentiated	1.904	0.063	6.712 (0.901-50.025)
Lowly differentiated	1.711	0.092	5.533 (0.756-40.507)
Undifferentiated	1.796	0.091	6.025 (0.752-48.275)
Liver metastases
Yes			1.000 (reference)			1.000 (reference)
No	-0.507	0.048	0.602 (0.367-0.994)	-0.334	0.211	0.716 (0.425-1.208)
Peritoneal metastases
Yes			1.000 (reference)
No	-0.452	0.070	0.637 (0.390-1.038)
Lung metastases
Yes			1.000 (reference)
No	0.046	0.909	1.047 (0.477-2.299)
Bone metastases
Yes			1.000 (reference)
No	-0.539	0.183	0.583 (0.264-1.290)
Treatment options
Chemotherapy			1.000 (reference)
Immunotherapy	-0.201	0.580	0.818 (0.402-1.665)
Combination therapy	-0.305	0.272	0.737 (0.428-1.269)
NLR	0.558	< 0.001	1.748 (1.318-2.318)	0.443	0.003	1.557 (1.157-2.094)
PLR	0.009	0.004	1.009 (1.003-1.015)	0.009	0.003	1.009 (1.003-1.015)
LMR	-0.317	0.021	0.728 (0.556-0.954)	-0.276	0.046	0.759 (0.578-0.995)
SII	0.005	< 0.001	1.005 (1.003-1.008)	0.004	0.005	1.004 (1.001-1.006)

HR: Hazard ratio; 95%CI: 95% confidence interval; BMI: Body mass index; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; SII: Systemic immune-inflammation index.