EPZ020411, a PRMT6 inhibitor, suppresses colorectal cancer cell proliferation, migration, and invasion through targeting the TGM2/MAPK axis

Figure 6 EPZ020411 inhibits the growth of colorectal cancer subcutaneous tumors and affects transglutaminase 2 expression. A: Mice body weights; B-D: Tumor growth curves (B), representative images of excised tumors (C), and tumor weights (D); E: Representative hematoxylin and eosin staining images of organs. Original magnification (scale bar: 100 μm); F: Representative immunohistochemistry staining of transglutaminase 2 in subcutaneous tumors from EPZ020411-treated mice. Original magnification (scale bar: 100 μm). Error bars represented the mean ± SEM. ^aP < 0.01, ^bP < 0.001. TGM2: Transglutaminase 2.