EPZ020411, a PRMT6 inhibitor, suppresses colorectal cancer cell proliferation, migration, and invasion through targeting the TGM2/MAPK axis

Figure 5 Transglutaminase 2 overexpression rescues EPZ020411-inhibited migration and invasion in colorectal cancer cells. A and B: Transwell assays showing the migration and invasion of HCT116 (A) and CACO-2 (B) cells under the indicated treatments (control, EPZ020411, and EPZ020411 + transglutaminase 2 overexpression); C and D: Wound healing assays assessing the migratory ability of HCT116 (C) and CACO-2 (D) cells under the same treatment conditions. Data are presented as mean ± SD from three independent experiments (n = 3). Error bars represented the mean ± SEM. ^aP < 0.01, ^bP < 0.001. TGM2: Transglutaminase 2.