EPZ020411, a PRMT6 inhibitor, suppresses colorectal cancer cell proliferation, migration, and invasion through targeting the TGM2/MAPK axis

Figure 2 EPZ020411 inhibits the migration and invasion of colorectal cancer cells in a concentration-dependent manner. A and B: Transwell assays showing the effects of increasing concentrations of EPZ020411 on the migration and invasion of HCT116 (A) and CACO-2 (B) cells; C and D: Wound healing assays assessing the migratory ability of HCT116 (C) and CACO-2 (D) cells after EPZ020411 treatment. Data are presented as mean ± SD from three independent experiments (n = 3). Error bars represented the mean ± SEM. ^bP < 0.001.