EPZ020411, a PRMT6 inhibitor, suppresses colorectal cancer cell proliferation, migration, and invasion through targeting the TGM2/MAPK axis

Figure 1 Effects of EPZ020411 at varying concentrations on the proliferation of colorectal cancer cells. A and B: IC₅₀ values were calculated by nonlinear regression analysis; C and D: Representative images of colony formation assays of HCT116 (C) and CACO-2 (D) cells treated with increasing concentrations of EPZ020411; E and F: EdU staining was performed to detect the proliferation of HCT116 (E) and CACO-2 (F) cells treated with increasing concentrations of EPZ020411 (scale bar: 50 μm). Error bars represented the mean ± SEM. ^bP < 0.001.