Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities

doi:10.4251/wjgo.123002

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 123002
Published online Sep 15, 2026. doi: 10.4251/wjgo.123002

Table 4 Gastric cancer evidence and clinical implications

Pathway/biomarker	Evidence in gastric cancer	Potential clinical implication
FDX1	Linked to cuproptosis sensitivity, copper-lactylation signaling, and immune infiltration in gastric cancer-related studies[97,121,122,131,132]	Candidate marker for cuproptosis susceptibility and rational selection of copper-modulating strategies[97,121,122,131,132]
DLAT/LIAS/LIPT1/DLD (lipoylation-related genes)	Altered expression of lipoylation-related genes has been associated with gastric cancer metabolism and prognosis[47,49-50,122]	May help define tumors with mitochondrial metabolic dependence and potential vulnerability to cuproptosis induction[31,47,122]
SLC31A1/ATP7A/ATP7B (copper transporters)	Copper transporter dysregulation may affect intracellular copper accumulation, angiogenesis, and response to platinum-based therapy[16,52-56]	Potential targets to enhance copper-mediated cytotoxicity or overcome chemotherapy resistance[52-56]
AOC1	AOC1 down-regulation suppresses AKT signaling, epithelial-mesenchymal transition, proliferation, invasion, and migration in gastric cancer cells[124]	Candidate therapeutic and prognostic biomarker linked to tumor growth and metastasis[124]
ITGB1	High ITGB1 expression is associated with poor prognosis in diffuse gastric cancer and may reduce sensitivity to copper ionophores[125,126]	Potential stratification marker and actionable node for enhancing cuproptosis-based therapy[125,126]
SERPINE1	Elevated SERPINE1 expression in gastric adenocarcinoma is associated with proliferation, migration, and immunosuppressive features[128-130]	Candidate prognostic and immune-related marker that may guide combination strategies[128-130]

Cuproptosis-related pathways and candidate biomarkers in gastric cancer. FDX1: Ferredoxin 1; DLAT: Dihydrolipoamide S-acetyltransferase; LIAS: Lipoic acid synthetase; LIPT1: Lipoyltransferase 1; DLD: Dihydrolipoamide dehydrogenase; ATP7A/ATP7B: ATPase copper-transporting alpha/bet; SLC31A1: Solute carrier family 31 member 1; AOC1: Amine oxidase copper-containing 1; SERPINE1: Serpin family E member 1; ITGB1: Integrin β1.

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Citation: Fang YP, Liu SN, Liu FP, Gong JW, Zhang YF, Lu JH, Liu JW, Wang Q, Chen X. Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2026; 18(9): 123002
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/123002.htm
DOI: https://dx.doi.org/10.4251/wjgo.123002

Fang YP, Liu SN, Liu FP, Gong JW, Zhang YF, Lu JH, Liu JW, Wang Q, Chen X. Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2026; 18(9): 123002 [DOI: 10.4251/wjgo.123002]

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