Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities

doi:10.4251/wjgo.123002

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 123002
Published online Sep 15, 2026. doi: 10.4251/wjgo.123002

Table 3 Biological roles

Pathway/biomarker	Role in copper metabolism or cuproptosis
FDX1	Reduces Cu²⁺ to Cu⁺ and promotes lipoylation-dependent aggregation of TCA-cycle proteins, especially DLAT[31-33,97,122]
DLAT/LIAS/LIPT1/DLD (lipoylation-related genes)	Core components of mitochondrial protein lipoylation and lipoylated TCA-cycle protein aggregation during cuproptosis[31,34,43,47]
SLC31A1/ATP7A/ATP7B (copper transporters)	Regulate copper uptake and efflux; ATP7A/ATP7B can also influence platinum-drug transport and chemoresistance[11,16,30,52-56]
AOC1	Copper-containing amine oxidase involved in polyamine catabolism and ROS-related metabolic stress[123,124]
ITGB1	Integrin-mediated regulator of cell adhesion, metabolism, migration, and cuproptosis-related phenotypes[125,126]
SERPINE1	Regulates extracellular matrix remodeling, EMT, angiogenesis, apoptosis, and immune infiltration[127-130]

Cuproptosis-related pathways and candidate biomarkers in gastric cancer. FDX1: Ferredoxin 1; TCA: Tricarboxylic acid; DLAT: Dihydrolipoamide S-acetyltransferase; LIAS: Lipoic acid synthetase; LIPT1: Lipoyltransferase 1; DLD: Dihydrolipoamide dehydrogenase; ATP7A/ATP7B: ATPase copper-transporting alpha/bet; SLC31A1: Solute carrier family 31 member 1; AOC1: Amine oxidase copper-containing 1; ROS: Reactive oxygen species; EMT: Epithelial-mesenchymal transition; SERPINE1: Serpin family E member 1; ITGB1: Integrin β1.

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Citation: Fang YP, Liu SN, Liu FP, Gong JW, Zhang YF, Lu JH, Liu JW, Wang Q, Chen X. Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2026; 18(9): 123002
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/123002.htm
DOI: https://dx.doi.org/10.4251/wjgo.123002

Fang YP, Liu SN, Liu FP, Gong JW, Zhang YF, Lu JH, Liu JW, Wang Q, Chen X. Cuproptosis in gastric cancer: Mechanisms and therapeutic opportunities. World J Gastrointest Oncol 2026; 18(9): 123002 [DOI: 10.4251/wjgo.123002]

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