Gastric amphicrine carcinoma with leptomeningeal metastases: A case report

Figure 7 Pathological findings of the liver lesion and cerebrospinal fluid. A: Tumor cells exhibited marked atypia with nuclear displacement and a morphology resembling signet ring cells (hematoxylin and eosin [H&E], 400 ×); B and C: Insulinoma-associated protein 1 (INSM1) showed diffuse positive expression (EnVision, 200 ×); D and E: Diastase-Periodic Acid-Schiff (D-PAS) staining demonstrated the presence of mucin within the cytoplasm of tumor cells (Special stain, 400 ×); F: Tumor cells were relatively uniform in size, with inconspicuous nucleoli and eccentrically located nuclei, resembling signet ring cells; occasional tumor giant cells were noted (H&E, 400 ×); G: Tumor cells displayed features similar to those in panel D, with identifiable mitotic figures (H&E, 400 ×). CSF: Cerebrospinal fluid.