Clinical decision support for precolonoscopy cancer triage: A rule-out-oriented machine learning model for colorectal cancer risk

Figure 4 Decision curve analysis. Decision curve analysis based on out-of-fold predicted probabilities from repeated stratified cross-validation. A: Standard net benefit curves across threshold probabilities, comparing the full-feature, SHAP10, and SHAP5 models with “refer all” and “refer none” strategies; B: Rule-out-oriented clinical yield expressed as net avoided colonoscopies per 100 patients, calculated as true negatives gained minus harm-weighted false negatives. OOF: Out-of-fold; SHAP: SHapley Additive exPlanations; TN: True negative; FN: False negative.