Retrospective analysis of risk factors for left-sided vs right-sided colon cancer in a southern Chinese Han population

doi:10.4251/wjgo.121675

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World Journal of Gastrointestinal Oncology

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1948-5204

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Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 121675
Published online Sep 15, 2026. doi: 10.4251/wjgo.121675

Table 1 Clinical data, statistics, and comparison results of left-sided colorectal cancer and right-sided colorectal cancer groups, n (%) or mean ± SD

	L-CRC group, n = 1132	R-CRC group, n = 877	P value
Age (year)	54.13 ± 7.5	55.1 ± 6.7	0.0023
Male sex	832 (73.5)	468 (53.4)	< 0.0001
Smoking	786 (69.3)	128 (14.6)	< 0.0001
Alcohol drinking	236 (20.8)	184 (21)	0.9422
Hypertension	905 (79.9)	657 (74.9)	0.0072
Diabetic mellitus	95 (8.4)	41 (4.7)	0.0016
Hepatitis B virus infection	214 (18.9)	104 (11.9)	< 0.0001
Family history of CRC	80 (6.8)	13 (1.5)	< 0.0001
Family history of colorectal polyps	786 (69.4)	263 (30)	< 0.0001
Tumor stage			< 0.0001
I	60 (5.3)	48 (5.5)
II	90 (8.0)	28 (3.2)
III	678 (59.9)	290 (33.1)
IV	304 (26.9)	511 (58.3)
BMI (kg/m²)	26.72 ± 2.2	23.97 ± 1.9	< 0.0001
TG (mmol/L)	2.6 ± 1.3	3.1 ± 1.5	< 0.0001
LDL (mmol/L)	3.1 ± 1.0	2.7 ± 1.0	< 0.0001

L-CRC: Left-sided colorectal cancer; R-CRC: Right-sided colorectal cancer; CRC: Colorectal cancer; BMI: Body mass index; TG: Triglyceride; LDL: Low-density lipoprotein.

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Citation: Lai Y, Ye YF, Lin Y, Yu YF, Chen QK. Retrospective analysis of risk factors for left-sided vs right-sided colon cancer in a southern Chinese Han population. World J Gastrointest Oncol 2026; 18(9): 121675
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/121675.htm
DOI: https://dx.doi.org/10.4251/wjgo.121675

Lai Y, Ye YF, Lin Y, Yu YF, Chen QK. Retrospective analysis of risk factors for left-sided vs right-sided colon cancer in a southern Chinese Han population. World J Gastrointest Oncol 2026; 18(9): 121675 [DOI: 10.4251/wjgo.121675]

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