Clinicopathological features and prognosis of gastric adenocarcinoma with enteroblastic differentiation

Table 2 Univariate and multivariate complications logistic regression of gastric cancer with or without enteroblastic differentiation in China National Cancer Center

Factors	Univariate analysis			Multivariate analysis
	Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
Group
GC	1.000
GAED	0.660	0.325-1.341	0.250
Gender
Female	1.000
Male	0.441	0.191-1.019	0.055
Age, year
< 40	1.000
40-65	2.471	0.311-19.622	0.392
> 65	3.628	0.450-29.233	0.226
Smoking history
No	1.000
Yes	0.614	0.263-1.435	0.260
Drinking history
No	1.000
Yes	0.491	0.167-1.441	0.196
H. pylori
Negative	1.000			1.000
Positive	0.451	0.240-0.848	0.013	0.402	0.208-0.779	0.006
Tumor size (cm)
< 4.0	1.000
≥ 4.0	1.707	0.957-3.042	0.070
Tumor location
Proximal	1.000			1.000
Distal	0.281	0.129-0.612	0.001	0.288	0.128-0.647	0.003
Overlapping lesions	0.705	0.377-1.317	0.272	0.717	0.368-1.400	0.330
Surgical approach
Open surgery	1.000
Laparoscopy assisted surgery	2.301	0.668-7.928	0.187
Conversion to open surgery	3.462	0.715-16.754	0.123
Total laparoscopic surgery	1.558	0.389-6.235	0.531
Surgical duration (hour)
< 3.3	1.000			1.000
≥ 3.3	1.895	1.077-3.333	0.027	1.502	0.825-2.734	0.183
Blood transfusion
No	1.000
Yes	1.180	0.489-2.869	0.707
The number of lymph nodes retrieved
< 34	1.000
≥ 34	1.127	0.649-1.958	0.671
Lauren classification
Intestinal	1.000
Diffuse	0.492	0.234-1.033	0.061
Mixed	0.970	0.512-1.840	0.926
Borrmann classification
Borrmann I	1.000
Borrmann II	0.924	0.319-2.675	0.885
Borrmann III	1.196	0.416-3.442	0.740
Borrmann IV	0.733	0.174-3.084	0.672
Signet ring
No	1.000
Yes	0.480	0.225-1.024	0.578
Linitis plastica
No	1.000
Yes	1.312	0.350-4.915	0.687
Differentiation
Poor	1.000
Well	1.710	0.971-3.014	0.063
Moderate	0.463	0.058-3.723	0.469
HER2 score
0 (-)	1.000
1 (+)	1.107	0.537-2.278	0.784
2 (++)	2.351	0.050-5.265	0.377
3 (+++)	0.448	0.101-1.994	0.292
pTNM stage
I	1			1.000
II	2.718	1.161-6.359	0.021	1.966	0.707-5.464	0.195
III	1.870	0.8776-3.990	0.106	1.085	0.370-3.178	0.882
Lymphatic invasion
No	1.000			1.000
Yes	2.172	1.123-4.204	0.021	2.337	0.927-5.891	0.072
Vascular invasion
No	1.000
Yes	1.583	0.900-2.784	0.111
Perineural invasion
No	1.000
Yes	1.656	0.929-2.953	0.087
Vascular tumor thrombus
No	1.000
Yes	1.306	0.750-2.273	0.345

CI: Confidence interval; GC: Gastric cancer; GAED: Gastric adenocarcinoma with enteroblastic differentiation; H. pylori: Helicobacter pylori; TNM: Tumor-node-metastasis.