Clinicopathological features and prognosis of gastric adenocarcinoma with enteroblastic differentiation

doi:10.4251/wjgo.121562

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 121562
Published online Sep 15, 2026. doi: 10.4251/wjgo.121562

Table 1 Baseline characteristics of patients with gastric adenocarcinoma with enteroblastic differentiation and conventional gastric adenocarcinoma, n (%)

Variable	Category	GAED (n = 81)	Conventional gastric adenocarcinoma (n = 249)	P value
Gender	Male	65 (80.2)	198 (79.5)	0.887
Gender	Female	16 (19.8)	51 (20.5)
Age, years	Median (range)	62 (34, 76)	60 (21, 83)	0.200
Smoking history	No	60 (74.1)	217 (87.1)	0.008^a
Smoking history	Yes	21 (25.9)	32 (12.9)
Drinking history	No	66 (81.5)	227 (91.2)	0.024^a
Drinking history	Yes	15 (18.5)	22 (8.8)
Helicobacter pylori status¹	Positive	17 (81.0)	37 (59.7)	0.077
Helicobacter pylori status¹	Negative	4 (19.0)	25 (40.3)
Tumor size, cm	Median (range)	4.1 (1.8, 7.4)	4.5 (0.7, 9.5)	0.129
Tumor location	Proximal	23 (28.4)	86 (34.5)	< 0.001^a
	Distal	42 (51.9)	66 (26.5)
	Overlapping lesions	16 (19.7)	97 (39.0)
Surgical approach	Open surgery	10 (12.3)	20 (8.0)	0.532
	Laparoscopy-assisted surgery	54 (66.7)	167 (67.1)
	Conversion to open surgery	5 (6.2)	13 (5.2)
	Total laparoscopic surgery	12 (14.8)	49 (19.7)
Surgical duration, minute	Median (range)	190 (100, 368)	215 (76, 617)	0.002^a
Blood transfusion	Yes	12 (14.8)	21 (8.4)	0.133
Blood transfusion	No	69 (85.2)	228 (91.6)
Number of metastatic lymph nodes	Median (range)	5 (0, 35)	6 (0, 31)	0.708
Number of retrieved lymph nodes	Median (range)	36 (11, 80)	36 (3, 107)	0.852
Lauren classification	Intestinal	45 (60.0)	84 (37.1)	0.001^a
	Diffuse	10 (13.3)	75 (33.5)
	Mixed	20 (26.7)	66 (29.4)
Borrmann classification	Type I	8 (13.3)	11 (6.0)	0.111
	Type II	25 (41.7)	62 (33.9)
	Type III	23 (38.3)	88 (48.1)
	Type IV	4 (6.7)	22 (12.0)
Signet-ring cell component	No	73 (90.1)	178 (71.5)	0.001^a
Signet-ring cell component	Yes	8 (9.9)	71 (28.5)
Linitis plastica	No	78 (96.3)	239 (96.0)	0.900
Linitis plastica	Yes	3 (3.7)	10 (4.0)
Differentiation	Well	0 (0.0)	13 (5.2)	0.219
	Moderate	43 (53.1)	109 (43.8)
	Poor	38 (46.9)	127 (51.0)
HER2 score	0	41 (50.6)	170 (68.3)	0.012^a
	1+	24 (29.6)	39 (15.7)
	2+	8 (9.9)	25 (10.0)
	3+	8 (9.9)	15 (6.0)
T stage	I	16 (19.8)	47 (18.9)	0.145
	II	13 (16.0)	28 (11.2)
	III	27 (33.3)	63 (25.3)
	IV	25 (30.9)	111 (44.6)
N stage	0	26 (32.1)	99 (39.8)	0.352
	I	17 (21.0)	40 (16.1)
	II	16 (19.8)	35 (14.0)
	III	22 (27.1)	75 (30.1)
Pathological TNM stage	I	21 (25.9)	60 (24.1)	0.394
	II	25 (30.9)	61 (24.5)
	III	35 (43.2)	128 (51.4)
Metastasis or recurrence	No	44 (54.3)	172 (69.1)	0.022^a
Metastasis or recurrence	Yes	37 (45.7)	77 (30.9)
Lymphatic invasion	No	26 (32.1)	85 (34.1)	0.788
Lymphatic invasion	Yes	55 (67.9)	164 (65.9)
Vascular invasion	No	33 (41.6)	111 (44.6)	0.608
Vascular invasion	Yes	48 (58.4)	138 (55.4)
Perineural invasion	No	67 (82.7)	158 (63.5)	< 0.001^a
Perineural invasion	Yes	14 (17.3)	91 (36.5)
Vascular tumor thrombus	No	72 (88.9)	116 (46.6)	< 0.001^a
Vascular tumor thrombus	Yes	9 (11.1)	133 (53.4)
Postoperative complication	No	70 (86.4)	198 (79.5)	0.192
Postoperative complication	Yes	11 (13.6)	51 (20.5)
Postoperative hospital stay, days	Median (range)	12 (4, 55)	12 (2, 55)	0.727

^aP < 0.05.

¹Helicobacter pylori is only applicable to a certain group of patients.

GAED: Gastric adenocarcinoma with enteroblastic differentiation; TNM: Tumor-node-metastasis.

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Citation: Wen ZL, Ren H, Niu PH, Fei H, Li ZF, Zhao DB. Clinicopathological features and prognosis of gastric adenocarcinoma with enteroblastic differentiation. World J Gastrointest Oncol 2026; 18(9): 121562
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/121562.htm
DOI: https://dx.doi.org/10.4251/wjgo.121562

Wen ZL, Ren H, Niu PH, Fei H, Li ZF, Zhao DB. Clinicopathological features and prognosis of gastric adenocarcinoma with enteroblastic differentiation. World J Gastrointest Oncol 2026; 18(9): 121562 [DOI: 10.4251/wjgo.121562]

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