Spatial transcriptomics reveals tumor niche heterogeneity in advanced gastric cancer and suggests a tumor-promoting role for KRT6B

Figure 4 Niche-specific intercellular communication in sample P2. A: Heatmaps showing the overall interaction strengths among major cell types within N5; B: Bubble plots showing significant inferred ligand-receptor interactions targeting tumor epithelial cells (TECs) in N5. Dot size indicates the significance level, and color indicates communication probability; C: Spatial interaction networks of the MDK signaling pathway in N5. The background indicates the spatial distribution of major cell types within each niche; nodes denote cell types, and edges indicate inferred ligand-receptor interactions; D: Heatmaps showing the overall interaction strengths among major cell types within N4; E: Bubble plots showing significant inferred ligand-receptor interactions targeting TECs in N4. Dot size indicates the significance level, and color indicates communication probability; F: Spatial interaction networks of the MDK signaling pathway in N4. The background indicates the spatial distribution of major cell types within each niche; nodes denote cell types, and edges indicate inferred ligand-receptor interactions; G: Heatmaps showing the overall interaction strengths among major cell types within N2; H: Bubble plots showing significant inferred ligand-receptor interactions targeting TECs in N2. Dot size indicates the significance level, and color indicates communication probability; I: Spatial interaction networks of the MDK signaling pathway in N2. The background indicates the spatial distribution of major cell types within each niche; nodes denote cell types, and edges indicate inferred ligand-receptor interactions.